NRXN1 α+/- is associated with increased excitability in ASD iPSC-derived neurons

NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, and the latter is associated wit...

Source: BMC Neuroscience - September 15, 2021 Category: Neuroscience Authors: Sahar Avazzadeh, Leo R. Quinlan, Jamie Reilly, Katya McDonagh, Amirhossein Jalali, Yanqin Wang, Veronica McInerney, Janusz Krawczyk, Yicheng Ding, Jacqueline Fitzgerald, Matthew O ’Sullivan, Eva B. Forman, Sally A. Lynch, Sean Ennis, Niamh Feerick, Rich Tags: Research Source Type: research