Perioperative Normal Saline Administration and Delayed Graft Function in Patients Undergoing Kidney Transplantation: A Retrospective Cohort Study

ConclusionsHigh percent normal saline administration is associated with delayed graft function in kidney transplant recipients.Editor ’s PerspectiveWhat We Already Know about This TopicRandomized controlled trials of balanced crystalloidsversus normal saline have not demonstrated superiority of either strategy in the generalized surgical populationPatients undergoing kidney transplantation and receiving normal saline experience the metabolic complications of hyperchloremiaThe association of normal saline administration with delayed graft function, defined as renal replacement therapy within 1 week of transplant, is unclearWhat This Article Tells Us That Is NewIn a single-center analysis of 2,515 patients undergoing kidney transplantation between 2004 and 2015, delayed graft function occurred in 21% of patients receiving greater than or equal to 80% normal saline, in 17.5% of patients receiving between 30 and 80% normal saline, and in 15.8% of patients receiving less than or equal to 30% normal salineFor patients receiving greater than or equal to 80% normal saline compared with patients receiving less than or equal to 30% normal saline, the adjusted odds ratios for delayed graft function were 1.52 (95% CI, 1.05 to 2.21;P = 0.028) for deceased donor transplants (n = 1,472) and 1.66 (95% CI, 0.65 to 4.25;P = 0.287) for living donor transplants (n = 1,043)
Source: Anesthesiology - Category: Anesthesiology Source Type: research