Reversing Rivaroxaban Anticoagulation as Part of a Multimodal Hemostatic Intervention in a Polytrauma Animal Model

ConclusionsProthrombin complex concentrate effectively reduced blood loss, restored hemostasis, and balanced thrombin generation. A multimodal hemostatic approach using tranexamic acid plus fibrinogen concentrate enhanced the effect of low doses of prothrombin complex concentrate, potentially reducing the prothrombin complex concentrate doses required for effective bleeding control.Editor ’s PerspectiveWhat We Already Know about This TopicSignificant bleeding can occur after trauma, especially with preexisting anticoagulation. Despite multiple therapeutic approaches, optimal management remains to be determined.What This Article Tells Us That Is NewIn an animal model of rivaroxaban-treated pigs that underwent complex traumatic injury, prothrombin complex concentrates alone and in combination with tranexamic acid and fibrinogen concentrate effectively reduced blood loss, restored hemostasis, and improved thrombin generation.
Source: Anesthesiology - Category: Anesthesiology Source Type: research