Predictors and prognoses of epilepsy after anti-neuronal antibody-positive autoimmune encephalitis

Autoimmune encephalitis (AIE) is increasingly recognized as a heterogeneous group of conditions associated with anti-neural antibodies (Abs)[1]. These Abs can be classified into two groups according to their epitopes: Abs targeting intracellular neuronal antigens (INAbs); and Abs targeting neural surface antigens (NSAbs)[2]. The initial and common symptoms of AIE include seizures (of several different types), which occur at a high prevalence (50- 90%)[3, 4]. These seizures are reported to respond poorly to routine therapy with antiepileptic drugs (AEDs)[5].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research