Effect of Gambogic Acid on miR-199a-3p Expression and Cell Biological Behavior in Colorectal Cancer Cells

J Oncol. 2021 Aug 26;2021:5140621. doi: 10.1155/2021/5140621. eCollection 2021.ABSTRACTColorectal cancer (CC), as a malignancy threatening life and health, has a rising incidence in recent years. It has been reported that gambogic acid (GA) has antitumor activity in various tumors, but its effect on CC remains to be elucidated. In this investigation, the influence of GA nanoparticles on microRNA-199a-3p (miR-199a-3p) in CC was analyzed to provide a reliable reference for future clinical practice. Through PCR detection, we first determined that miR-199a-3p presented low expression in CC and had a significant effect in predicting the onset and prognosis of CC. Through in vitro experiments, the enhanced CC cell viability after inhibition was determined; however, decreased cell viability and increased miR-199a-3p level were also observed after GA nanoparticles addition. Hence, GA nanoparticles may influence CC cell biological behaviors by modulating miR-199a-3p, providing a novel treatment scheme for CC in the future.PMID:34484332 | PMC:PMC8416366 | DOI:10.1155/2021/5140621
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research

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Conditions:   Adenoma Colon;   Colorectal Cancer;   Colorectal Polyp;   Colonic Adenocarcinoma Intervention:   Sponsor:   Centre Hospitalier Universitaire de NÄ«mes Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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