Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway

CONCLUSION: Pravastatin ameliorates sepsis-induced ALI through improving alveolar endothelial barrier disruption via modulating Cav-1/eNOS pathway, which may be an effective candidate for treating septic ALI.PMID:34464887 | DOI:10.1016/j.intimp.2021.108077

Source: International Immunopharmacology - August 31, 2021 Category: Allergy & Immunology Authors: Yi Ren Liang Li Meng-Meng Wang Li-Ping Cao Zhao-Rui Sun Zhi-Zhou Yang Wei Zhang Peng Zhang Shi-Nan Nie Source Type: research