Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry

In multiple myeloma (MM), the t (11;14) (q13;q32) translocation [t (11;14)] is a common cytogenetic abnormality and the most frequently occurring translocation found in 15% to 24% of patients.1-4 Although t (11;14) is classified as standard risk according to International Myeloma Working Group guidelines,5 the prognostic effect of t (11;14) in MM has been evaluated in several studies with varying conclusions.2, 4, 6-11 Historically, the presence of t (11;14) was associated with favorable outcomes or limited impact.

Source: Clinical Lymphoma, Myeloma and Leukemia - August 29, 2021 Category: Hematology Authors: Cristina J. Gasparetto, Sundar Jagannath, Robert M. Rifkin, Brian G.M. Durie, Mohit Narang, Howard R. Terebelo, Kathleen Toomey, James W. Hardin, Lynne Wagner, Sikander Ailawadhi, James L. Omel, Shankar Srinivasan, Mazaher Dhalla, Donna Catamero, Amani Ki Source Type: research