Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF- α-TSG-6-mediated HC-HA formation

TNF- α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form...

Source: Arthritis Research and Therapy - August 20, 2021 Category: Rheumatology Authors: Diana C. Fasanello, Jin Su, Siyu Deng, Rose Yin, Marshall J. Colville, Joshua M. Berenson, Carolyn M. Kelly, Heather Freer, Alicia Rollins, Bettina Wagner, Felipe Rivas, Adam R. Hall, Elaheh Rahbar, Paul L. DeAngelis, Matthew J. Paszek and Heidi L. Reesin Tags: Research article Source Type: research