O-147 Differential seminal metabolomic signature is related to sperm quality

AbstractStudy questionWhat is the entire metabolomic profile of human semen and does the metabolic composition differ between men with good-quality and low-quality semen?Summary answerHuman semen contains ∼700 different metabolites, and the metabolomic signature differs between normozoospermic men and men with altered seminal parameters. What is known alreadySemen contains a wide diversity of metabolites as has been identified in single and targeted metabolite studies. The full composition of metabolites in human semen, however, is not known. The knowledge of the complete metabolic signature in semen and whether there are differences between metabolic composition and seminal quality could enhance our knowledge of possible factors involved in reduced sperm quality and male infertility.Study design, size, durationCase-control study, where a total of 100 men (age=  29.73±8.9 years) from March 2019 to March 2020 participated. The study was approved by the Ethics Committee of Investigación Biomédica de Andalucia.Participants/materials, setting, methodsSemen samples from 69 normozoospermic and 31 oligozoospermic men were collected at the University Hospital and sperm biobank (Ceifer Biobank - NextClinics). The complete metabolome from unprocessed seminal samples was analysed by  Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectroscopy (UPLC-MS/MS). Raw data were extracted, peak-identified and quality control processed using Metabolon’s hardware and software...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research