P –787 Impact of delaying ART to promote weight loss: a large multicentre study accounting for the combined effect of female/male age and body mass index (BMI)

AbstractStudy questionIs postponing the start of ART (to promote a reduction in female BMI) beneficial for cumulative live birth rates (CLBR) when accounting for the female/male ageing this delay will cause?Summary answerPostponing ART treatment in one year to promote female weight loss could be detrimental in women of advanced maternal age (AMA,>35 years-old).What is known alreadyOverweight/obese couples are frequently encouraged to lose weight prior to infertility treatment to enhance ART outcomes. However, a meaningful weight loss is often difficult to achieve for these couples, frequently taking at least one year to accomplish. Given that both female and male ageing are also important for ART success, we were interested in understanding the combined impact on CLBR of BMI reduction and ageing following a one-year delay.Study design, size, durationA retrospective study including patients performing their first ART cycle using autologous gametes between 2013 –2018 in one of 39 participating ART centres. Only GnRH antagonist cycles were included (n = 14260). CLBR was the primary outcome. Secondary outcomes included time-to-pregnancy, birthweight and gestational age.Participants/materials, setting, methodsPatients were subdivided according to female BMI (Kg/m2) in either underweight (<18.5), normal-weight (18.5 –24.9), overweight (BMI 25.0–29.9 kg/m2) and obese (≥30 kg/m2). Meaningful and extreme weight loss were defined as a reduction from obesity to eit...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research