P –595 Systematic dydrogesterone supplementation of artificial endometrial preparation cycles for frozen-thawed embryo transfer during Covid–19 pandemic: a good way to limit monitoring visits and optimize outcomes

AbstractStudy questionDoes systematic dydrogesterone supplementation in artificial cycles (AC) for frozen-thawed embryo transfer (FET) during Covid –19 pandemic modify outcomes compared to prior individualized supplementation adjusted on serum progesterone (P) levels ?Summary answerSystematic dydrogesterone supplementation in AC for FET is associated with similar outcomes compared to prior individualized supplementation in patients with low P levels.What is known alreadyIn AC for FET using vaginal P for endometrial preparation, low serum P levels following P administration have been associated with decreased pregnancy and live birth rates. This deleterious effect can be overcome by addition of other routes of P administration. We obtained effective results by adding dydrogesterone to vaginal P and postponing FET by one day in patients with low P levels. However, in order to limit patient monitoring visits and to schedule better FET activity during Covid –19 pandemic, we implemented a systematic dydrogesterone supplementation without luteal P measurement in artificial FET cycles.Study design, size, durationThis retrospective study aimed to analyse outcomes of 394 FET after 2 different protocols of artificial endometrial preparation. From September 2019 to Covid –19 lockdown on 15th March 2020, patients had serum P level measured on D1 of vaginal P administration. When P levels were< 11  ng/ml, dydrogesterone supplementation was administered and FET was postponed by ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research