Differential survival outcomes between de novo and secondary Acute Promyelocytic Leukemia: An updated population-based study

Whether the characteristics and outcome of secondary acute promyelocytic leukemia (s-APL) are similar to de no APL (dn-APL) remains unknown. Using the SEER database, we identified 3877 patients with APL diagnosed from 2000-2014, including 465 s-APL and 3412 dn-APL. Compared with dn-APL, s-APL were characterized by older median age and a higher early mortality rate. Multivariate Cox model showed s-APL, older age, earlier year of diagnosis, and male gender were independently associated with worse survival.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research