Mapping Arginase Expression with 18F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary {alpha}-Amino Acids

Conclusion: The new 18F-fluorinated arginase inhibitors have the potential to map increased arginase expression related to inflammatory and tumorigenic processes. 18F-FBMARS showed the highest arginase-mediated uptake in PET imaging and a significant difference between uptake in control and arginase-inhibited PC3 xenografted mice. These results encourage further research to examine the suitability of 18F-FBMARS for selecting patients for treatments with arginase inhibitors.

Source: Journal of Nuclear Medicine - July 30, 2021 Category: Nuclear Medicine Authors: Clemente, G. S., Antunes, I. F., Kurhade, S., van den Berg, M. P. M., Sijbesma, J. W. A., van Waarde, A., Buijsman, R. C., Willemsen-Seegers, N., Gosens, R., Meurs, H., Domling, A., Elsinga, P. H. Tags: Basic Science Investigations Source Type: research