Hemophagocytic lymphohistiocytosis in adult and pediatric patients

Hemophagocytic lymphohistiocytosis (HLH) describes a group of syndromes associated with immune system overstimulation.1 These syndromes can be divided into primary or familial and secondary or reactive.1 Primary HLH results from genetic mutations, whereas secondary HLH is attributed to viral infection, malignancy, or autoimmune condition.1 Diagnosis and management is based on HLH-2004, the most widely used diagnostic criteria of HLH.2 Our study reviews adult and pediatric patients with HLH at our institution to improve the current understanding of this condition.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research