< i > In vitro < /i > activity of SPR719 against < i > Mycobacterium ulcerans < /i > , < i > Mycobacterium marinum < /i > and < i > Mycobacterium chimaera < /i >

by Sacha J. Pidot, Jessica L. Porter, Troy Lister, Timothy P. Stinear Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are limited. However, there has been progress in recent years in the development of new antimycobacterial drugs. Here, we investigate thein vitro activity of SPR719, a novel aminobenzimidazole antibiotic and the active form of the clinical-stage compound, SPR720, against several isolates ofMycobacterium ulcerans,Mycobacterium marinum andMycobacterium chimaera. We show that SPR719 is active against these NTM species with a MIC range of 0.125 –4 μg/ml and that this compares favorably with the commonly utilized antimycobacterial antibiotics, rifampicin and clarithromycin. Our findings suggest that SPR720 should be further evaluated for the treatment of NTM infections.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research