Better Strategies Needed for Managing NAFLD in Adults

MONDAY, July 26, 2021 -- Effective screening, diagnosis, and management strategies are needed for patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), according to a special report published online July 26...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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This study aimed to clarify the association between NAFLD and the incidence of asthma using fatty liver index (FLI), a surrogate marker of NAFLD, in a large population-based cohort.Method: We selected 160,603 healthy individuals without comorbidities from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) during 2009–2014. The association between FLI and asthma incidence was analyzed using multivariate Cox proportional hazards models.Result: During a median of 5.08 years’ follow-up, 16,377 subjects (10.2%) were newly diagnosed with asthma and categorized into three groups according to FLI. ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
AbstractBackground and aimsAcute-on-chronic liver failure (ACLF) is considered a main prognostic event in patients with chronic liver disease (CLD). We analyzed the 28-day and 90-day mortality in ACLF patients with or without underlying cirrhosis enrolled in the ACLF Research Consortium (AARC) database.MethodsA total of 1,621 patients were prospectively enrolled and 637 (39.3%) of these patients had cirrhosis. Baseline characteristics, complications and mortality were compared between patients with and without cirrhosis.ResultsAlcohol consumption was more common in cirrhosis than non-cirrhosis (66.4% vs. 44.2%,p 
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Maria Sotiropoulou, Ioannis Katsaros, Michail Vailas, Irene Lidoriki, George V Papatheodoridis, Nikolaos G Kostomitsopoulos, Georgia Valsami, Alexandra Tsaroucha, Dimitrios SchizasSaudi Journal of Gastroenterology 2021 27(6):319-330Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting almost one-third of the general population and 75% of obese patients with type 2 diabetes. The aim of this article is to review the current evidence concerning the role of quercetin, a natural compound and flavonoid, and its possible therapeutic effects on this modern-day disease. Despite the...
Source: The Saudi Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Trends Mol Med. 2021 Nov 20:S1471-4914(21)00277-X. doi: 10.1016/j.molmed.2021.10.005. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a metabolic disorder affecting over one quarter of the global population. Liver fat accumulation in NAFLD is promoted by increased de novo lipogenesis leading to the development of a proatherosclerotic lipid profile and atherosclerotic cardiovascular disease (CVD). The CVD component of NAFLD is the main determinant of patient outcome. The farnesoid X receptor (FXR) and the G protein bile acid-activated receptor 1 (GPBAR1) are bile acid-activated receptors that modu...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
In a mouse model of aging-related hepatic steatosis, 588 aging-related differentially expressed proteins (DEPs) were identified in the livers of old mice using liquid chromatography –mass spectrometry. Among them, AIMP2 was the most significantly upregulated protein. Aging induced the activation of O-GlcNAcylation and increased AIMP2 O-GlcNAcylation. The AIMP2 O-GlcNAcylation promoted PARP1 overactivation, thereby causing liver NAD+ deletion and hepatic steatosis. AbstractThe prevalence of non-alcoholic fatty liver disease (NAFLD) increases with aging. However, the mechanism of aging-related NAFLD remains unclear. He...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Article Source Type: research
Conclusions: Results suggest potential phenotypical differences between adolescents presenting for MBS with/without NAFLD, with implications for behavioral/psychosocial targets for screening and intervention. Replication should occur in a sample with greater gender and ethnic diversity to improve generalizability. Understanding differences in the context of surgical weight loss and comorbidity resolution is indicated.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Article: Hepatology Source Type: research
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi-organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases, although the onset and transition of MAFLD stages still remains unclear. Nevertheless, innate and adaptive immune responses seem to play an essential role in the establishment and further progression of this disease. The immune system is responsible of safeguard and preserves organs and systems function, and might be altered un...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The association of non-alcoholic fatty liver disease (NAFLD) with dietary factors is well established but not thoroughly investigated. This systematic review and meta-analysis synthesizes available evidence regarding the effect of nutrition on the presence and severity of NAFLD.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Metabolic Syndrome and Related Disorders, Ahead of Print.
Source: Metabolic Syndrome and Related Disorders - Category: Endocrinology Authors: Source Type: research
In this study, we used network pharmacology to predict the potential mechanism of HX on NAFLD. Pharmacological experiments were used to verify the effect of HX on the functions of NAFLD. Network pharmacology identified nine components that interacted with 82 NAFLD-related targets, revealing four target genes: TNF, IL6, TP53, and AKT1. HX prevents the development and progression of NAFLD through different pathways and targets with quercetin-regulated lipid metabolism, anti-inflammatory, and anti-oxidant pathways playing an essential role in the treatment of NAFLD. Compared with feeding HFD, HX significantly attenuated lipid...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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