Structures and implications of TBP-nucleosome complexes [Biophysics and Computational Biology]

The TATA box-binding protein (TBP) is highly conserved throughout eukaryotes and plays a central role in the assembly of the transcription preinitiation complex (PIC) at gene promoters. TBP binds and bends DNA, and directs adjacent binding of the transcription factors TFIIA and TFIIB for PIC assembly. Here, we show that...

Source: Proceedings of the National Academy of Sciences - July 23, 2021 Category: Science Authors: Haibo Wang, Le Xiong, Patrick Cramer Tags: Inaugural Articles, Biophysics and Computational Biology Biological Sciences Source Type: research