Cancers, Vol. 13, Pages 3716: Primary Aldosteronism: Metabolic Reprogramming and the Pathogenesis of Aldosterone-Producing Adenomas

In conclusion, APAs exhibit metabolic reprogramming towards fatty acid β-oxidation and glycolysis. Increased lipid metabolism via PPARα may serve as a key mechanism to modulate lipid peroxidation, a hallmark of regulated cell death by ferroptosis. These findings highlight survival advantages for APA tumor cells with metabolic reprogramming properties.

Source: Cancers - July 23, 2021 Category: Cancer & Oncology Authors: Siyuan Gong Martina Tetti Martin Reincke Tracy Ann Williams Tags: Article Source Type: research