Sirtuins Expression in the Hippocampus and Buccal Epithelium of Elderly and Senile Individuals with Alzheimer ’s Disease

This article examines the age-related dynamics of SIRT1, 3, 5, and 6 expression in patients with AD and in healthy individuals with immunohistochemistry and immunocytochemis try methods via immunofluorescent confocal microscopy. In elderly and senile health individuals, the SIRT1, 3, 5, and 6 expression in the hippocampus and buccal epithelium did not differ significantly. In AD patients, the SIRT1, 3, 5, and 6 expression in the hippocampus and buccal epithelium decreas e by 1.5–5 times as compared with healthy elderly and senile individuals. The SIRT5 expression in the hippocampus and buccal epithelium does not depend on the age or AD diagnosis. Thus, the SIRT 1, 3, and 6 expression in the buccal epithelium can be a marker for intravital, noninvasive AD diagno sis in elderly and senile individuals.
Source: Advances in Gerontology - Category: Geriatrics Source Type: research