The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult < i > Schistosoma species < /i >

by J. Mark F. Gardner, Nuha R. Mansour, Andrew S. Bell, Helena Helmby, Quentin Bickle Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the properties of a series of compounds we discovere d through high throughput screening and have designed candidates for clinical development. The best compounds demonstrate clearance of both juvenile and adultS.mansoni worms in a mouse model of infection from a single oral dose of
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research