You ’re Missing Microbes. But Is ‘Rewilding’ the Way to Get Them Back?

The science behind the idea of restoring the intestinal microbiome to an ancestral state is shaky, skeptics say, and in some cases unethical.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Hadza Tribe Microbiology Digestive Tract Diet and Nutrition Feces Bowels Obesity Fiber (Dietary) Immune System Sonnenburg, Justin L Leach, Jeff Tanzania Research Probiotics Bacteria Science (Journal) Source Type: news

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Amand Trefoil Factor Family Member 2 (TFF2) belongs to TFF family peptides that includes TFF1, TFF2, TFF3. TFF2 is mainly known for its roles in the mucosal protection. In the context of obesity and high fat diet (HFD), Tff2 has been characterized as a HFD-induced gene. The knock-out of Tff2 in mice lead to the protection from HFD-induced obesity with a metabolic profile towards a negative energy balance. Such HFD-specific expression gives Tff2 a pattern worth exploring in biomedical research. Indeed, measuring TFF2/TFF2/Tff2 expression in biological samples following the ingestion of high-fat diet reflects the biologi...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Opinion Source Type: research
Conclusions. While more data are needed to confirm these preliminary findings, the results suggest caution is necessary in using BIA to assess aspects of youth health and weight status, especially in males, healthy weight, and teens. However, these preliminary findings do indicate that phase angle maybe be a valuable, non-invasive tool for identifying youth who are heading towards obesity and/or obesity-related health consequences.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
et I. Boomsma In recent years, evidence has accumulated with regard to the ubiquity of pleiotropy across the genome, and shared genetic etiology is thought to play a large role in the widespread comorbidity among psychiatric disorders and risk factors. Recent methods investigate pleiotropy by estimating genetic correlation from genome-wide association summary statistics. More comprehensive estimates can be derived from the known relatedness between genetic relatives. Analysis of extended twin pedigree data allows for the estimation of genetic correlation for additive and non-additive genetic effects, as well as a share...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Surg Obes Relat Dis. 2021 Aug 28:S1550-7289(21)00416-0. doi: 10.1016/j.soard.2021.08.017. Online ahead of print.NO ABSTRACTPMID:34561170 | DOI:10.1016/j.soard.2021.08.017
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - Category: Surgery Authors: Source Type: research
CONCLUSIONS: The high point, one-year, and lifetime prevalence of LBP in Brazil indicates that there is a need for coordinated efforts from government, the private sector, universities, health workers, and civil society to deliver appropriate management of LBP in middle-income countries.PMID:34561187 | DOI:10.1016/j.bjpt.2021.07.004
Source: Physical Therapy - Category: Physiotherapy Authors: Source Type: research
Exp Gerontol. 2021 Sep 22:111561. doi: 10.1016/j.exger.2021.111561. Online ahead of print.ABSTRACTThe number of adults 65 years and older is increasing worldwide and will represent the 20% of the population by 2030. Half of them will suffer from obesity. The decline in muscle mass and strength, known as sarcopenia, is very common among older adults with obesity (sarcopenic obesity). Sarcopenic obesity is strongly associated with frailty, cardiometabolic dysfunction, physical disability, and mortality. Increasing efforts have been hence made to identify effective strategies able to promote healthy aging and curb the obesity...
Source: Experimental Gerontology - Category: Geriatrics Authors: Source Type: research
CONCLUSION: Exercise is integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. Intensity of exercise need not improve cardinal features of metabolic syndrome [e.g. weight, glucose control] to exert beneficial effects.PMID:34561989 | DOI:10.2174/1573399817666210923125832
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Source Type: research
CONCLUSIONS: These HFD-induced increases in pro-inflammatory cytokine expression levels and NF-κB and MAPKs signaling pathway activation in reproductive organs support the notion that increases of adipocytes resident and inflammatory status are symptomatic of female fertility impairment in obese mice.PMID:34560886 | DOI:10.1186/s12958-021-00833-x
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Source Type: research
Brain Behav Immun. 2021 Sep 22:S0889-1591(21)00553-5. doi: 10.1016/j.bbi.2021.09.009. Online ahead of print.ABSTRACTInflammation is increasingly recognised to play a major role in gene-environment interactions in neurodevelopmental disorders (NDDs). The effects of aberrant immune responses to environmental stimuli in the mother and in the child can affect neuroimmune signalling that is central to brain development. Toll-like receptors (TLR) are the best known innate immune pattern and danger recognition sensors to various environmental threats. In animal models, maternal immune activation (MIA), secondary to inflammatory f...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Source Type: research
Appetite. 2021 Sep 22:105707. doi: 10.1016/j.appet.2021.105707. Online ahead of print.ABSTRACTBACKGROUND: Emotional eating has emerged as a contributing factor to overeating, potentially leading to obesity or disordered eating behaviors. However, the underlying biological mechanisms related to emotional eating remain unclear. The present study examined emotional, hormonal, and neural alterations elicited by an acute laboratory stressor in individuals with and without emotional eating.METHODS: Emotional (n = 13) and non-emotional eaters (n = 15) completed two main study visits, one week apart: one visit included a Stress ve...
Source: Appetite - Category: Nutrition Authors: Source Type: research
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