Quantification of persister formation of Escherichia coli leveraging electronic cell counting and semi-mechanistic pharmacokinetic/pharmacodynamic modelling

ConclusionsThe developed pharmacokinetic/pharmacodynamic model adequately characterized growth-kill behaviour of threeE. coli isolates and unveiled strain-specific levofloxacin potencies and persister formation. The mimicked dosing regimens did not eradicate the resistant isolates and enhanced persister formation to a strain-specific extent.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research