Active B-Type Natriuretic Peptide Measured by Mass Spectrometry and Response to Sacubitril/Valsartan

B-type natriuretic peptide (BNP) immunoassays (BNPia) do not differentiate active and inactive forms. Inactive NT-proBNP is used to track heart failure (HF) during treatment with sacubitril/valsartan, which inhibits BNP degradation. Mass spectrometry (MS) may better assess effects of HF treatment on biologically active BNP1-32.

Source: Journal of Cardiac Failure - June 13, 2021 Category: Cardiology Authors: Erica M. Dillon, Shouzuo D. Wei, Deepak K. Gupta, Hui Nian, Brooks S. Rodibaugh, Katherine N. Bachmann, Allen J. Naftilan, Lynne W. Stevenson, Nancy J. Brown Source Type: research