Histone Deacetylase 4 Controls Extracellular Matrix Production in Orbital Fibroblasts from Graves' Ophthalmopathy Patients

CONCLUSION: Our data indicated for the first time that altered HDAC4 regulation along with H3K9 hypoacetylation might represent a mechanism that contributes to excessive proliferation and extracellular matrix production by orbital fibroblasts in GO. HDAC4 might represent a novel target for GO therapy.PMID:34235979 | DOI:10.1089/thy.2020.0948

Source: Thyroid : official journal of the American Thyroid Association - July 8, 2021 Category: Endocrinology Authors: Supanuch Ekronarongchai Tanapat Palaga Preamjit Saonanon Vannakorn Pruksakorn Nattiya Hirankarn P Martin van Hagen Willem A Dik Sita Virakul Source Type: research