Measurement of urinary Dickkopf-3 uncovered silent progressive kidney injury in patients with chronic obstructive pulmonary disease.

Chronic kidney disease (CKD) represents a global public health problem with high disease related morbidity and mortality. Since CKD etiology is heterogeneous, early recognition of patients at risk for progressive kidney injury is important. Here, we evaluated the tubular epithelial derived glycoprotein dickkopf-3 (DKK3) as a urinary marker for the identification of progressive kidney injury in a non-CKD cohort of patients with chronic obstructive pulmonary disease (COPD) and in an experimental model.

Source: Kidney International - July 5, 2021 Category: Urology & Nephrology Authors: Stefan J. Schunk, Christoph Beisswenger, Felix Ritzmann, Christian Herr, Martina Wagner, Sarah Triem, Gregor H ütter, David Schmit, Stephen Zewinger, Tamim Sarakpi, Anja Honecker, Peer Mahadevan, Peter Boor, Stefan Wagenpfeil, Rudolf Jörres, Henrik Watz Tags: clinical investigation Source Type: research