Peptides With Laminin Activity

Technology Bundle IDE-521-1986-3 Peptides With Laminin ActivityLinked IDTAB-95Lead InventorsYoshihiko Yamada (NIDCR)Co-InventorsFrank Robey (NIDCR)George Martin (NIDCR)Hynda Kleinman (NIDCR)Jeannette Graf ()Makoto Sasaki ()Yukihide Iwamoto ()Development StagesPre-clinical (in vivo)ICsNIDCRPeptides with laminin activity, including YIGSR, are claimed. These peptides block angiogenesis, alter the formation of capillary structures by endothelial cells, prevent the formation of excess blood vessels in tissue and inhibit in vivo tumor cell colonization of tissues. These peptides can be used, among other things, to inhibit metastasis. {RefNo is 95 }Commercial Applicationscancer therapeuticresearch reagentCompetitive Advantagesencourage cell adhesioninhibits metastasis and angiogenesisRequest More InfoLicensing Contact:Vladimir Knezevic, M.D.vlado.knezevic@nih.govPhone: 301.443.5560Intellectual PropertiesUS Pat5,092,885Issued 1992-03-03PublicationsJ Graf, Y Iwamoto, M Sasaki, GR Martin, HK Kleinman, FA Robey, Y Yamada. Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 1987 Mar 27;48(6):989-9.K Yamamura, MC Kibbey, SH Jun, HK Kleinman. Effect of Matrigel and laminin peptide YIGSR on tumor growth and metastasis. Semin Cancer Biol 1993 Aug; 4(4):259-65.M Nomizu, K Yamamura, HK Kleinman, Y Yamada. Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis. Cancer Res 19...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research