Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells

ConclusionsThus, our data suggest that caspase-1, IL-1 β and IL-18 may contribute to the inflammatory status observed in SCA and that HU treatment may not interfere in this inflammatory pathway.

Source: Inflammation Research - July 1, 2021 Category: Research Source Type: research