PHF19 activates Hedgehog signaling and promotes tumorigenesis in hepatocellular carcinoma

In this study, we show that the short isoform of PHD finger protein 19 (PHF19) interacts with β-TrCP, the E3 ligase of Gli1, and that knocking down PHF19 promotes the ubiquitination of Gli1. In a biological function study, PHF19 was found to promote the growth of HCC cells both in liquid culture and in soft agar. Moreover, knocking out PHF19 in a HCC mouse model (MycF/F) using the hydrodynamic method inhibited tumorigenesis and improved survival. Taken together, these results demonstrate that PHF19 promotes the growth of HCC cells by activating the Hedgehog signaling pathway.PMID:34129846 | DOI:10.1016/j.yexcr.2021.112690

Source: Experimental Cell Research - June 15, 2021 Category: Cytology Authors: Shi Xiaoyun Zi Yuyuan Xing Jie Nie Yingjie Xie Qing Deng Yuezhen Xin Haiguang Source Type: research