Anesthesia-induced Recognition Deficit Is Improved in Postnatally Gonadectomized Male Rats

Conclusions: The absence of testosterone does not block cell death after anesthesia in specific brain regions of interest; however, does provide some neuroprotection as evidenced by the improved cognitive test performance during adulthood. These findings suggest that testosterone may be mechanistically involved in the sex-specific effects of anesthetic injury on the developing brain by extending the vulnerable period in male rats.
Source: Journal of Neurosurgical Anesthesiology - Category: Anesthesiology Tags: Laboratory Investigation Source Type: research