The aromatase inhibitor letrozole restores FADS2 function in ER+ MCF7 human breast cancer cells
DNA amplification is a common mechanism leading to oncogenic activation in cancers [1-3]. Several oncogenes map to the human chromosome 11q13 (HSA 11q13), established as among the most frequently amplified genomic regions in a number of human cancers, including breast cancer (BC) [2, 4-8]. The 11q13 region is amplified in 15 –20% of BC and comprises multiple amplicons highly variable in size, spanning several Mb of DNA from 11q12.2 to 11q14.1 [9-14]. 11q13 amplification in BC is associated with estrogen receptor (ER) expression, resistance to hormone therapy and poor prognosis [5, 14-17].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Hui Gyu Park, Jae Hun Kim, Andrew N. Dancer, Kumar S. Kothapalli, J. Thomas Brenna Source Type: research
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