Current fluconazole treatment regimens result in under-dosing of critically ill adults during early therapy

ConclusionCurrent fluconazole dosing regimens do not achieve adequate early target attainment in critically ill adults, particularly in those who are overweight, have higher creatinine clearance, or are undergoing CRRT. Current fluconazole dosing strategies are generally inadequate to treat organisms with an MIC of ≥4 mg/L.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research