Faecal microbiota transplantation influences procarcinogenic Escherichia coli in recipient recurrent Clostridioides difficile patients

Patients suffering from multiple recurrent Clostridioides difficile infections (rCDI) have a disturbed gut microbiota, which can be restored by faecal microbiota transplantation (FMT). Despite extensive screening, healthy faeces donors may carry bacteria in their intestinal tract that could have long-term health effects, such as potentially procarcinogenic pks+ Escherichia coli. Here, we aim to determine whether the pks abundance and persistence of pks+ E. coli is influenced by pks-status of the donor faeces.

Source: Gastroenterology - June 10, 2021 Category: Gastroenterology Authors: Sam Nooij, Quinten R. Ducarmon, Jeroen F.J. Laros, Romy D. Zwittink, Jason M. Norman, Wiep Klaas Smits, Hein W. Verspaget, Josbert J. Keller, Elisabeth M. Terveer, Ed J. Kuijper, working group of the Netherlands Donor Feces Bank Source Type: research