Type I interferon detection in autoimmune diseases: challenges and clinical applications

Expert Rev Clin Immunol. 2021 Jun 7. doi: 10.1080/1744666X.2021.1939686. Online ahead of print.ABSTRACTINTRODUCTION: Accumulating data highlights that dysregulation of type I interferon (IFN) pathways plays a central role in the pathogenesis of several systemic and organ specific autoimmune diseases. Advances in understanding the role of type I IFNs in these disorders can lead to targeted drug development as well as establishing potential disease biomarkers.AREAS COVERED: Here, we summarize current knowledge regarding the role of type I IFNs in the major systemic, as well as organ specific, autoimmune disorders, including prominent inflammatory CNS disorders like multiple sclerosis.EXPERT OPINION: Type I IFN involvement and its clinical associations in a wide spectrum of autoimmune diseases represents a promising area for research aiming to unveil common pathogenetic pathways in systemic and organ specific autoimmunity.PMID:34096436 | DOI:10.1080/1744666X.2021.1939686
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research