Life-threatening PPHN refractory to nitric oxide: proposal for a rational therapeutic algorithm

Conclusion: We offer a rational clinical algorithm to guide the treatment of refractory PPHN based on expert advice and the more recent pathobiology and pharmacology knowledge.What is Known:•Refractory PPHN occurs in 30 –40% of iNO-treated neonates and represents a significant clinical problem. Several pulmonary vasodilators have become available thanks to a better understanding of pulmonary hypertension pathobiology.What is New:•Available vasodilators have different pharmacology, mechanisms of action and may provide additive effect. We provide a rational clinical algorithm to guide the treatment of refractory PPHN based on expert advice and the more recent pathobiology and pharmacology knowledge.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research