AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency [Cell Biology]

Somatic cell transcription factors are critical to maintaining cellular identity and constitute a barrier to human somatic cell reprogramming; yet a comprehensive understanding of the mechanism of action is lacking. To gain insight, we examined epigenome remodeling at the onset of human nuclear reprogramming by profiling human fibroblasts after fusion...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Cell Biology Biological Sciences Source Type: research