AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency [Cell Biology]
Somatic cell transcription factors are critical to maintaining cellular identity and constitute a barrier to human somatic cell reprogramming; yet a comprehensive understanding of the mechanism of action is lacking. To gain insight, we examined epigenome remodeling at the onset of human nuclear reprogramming by profiling human fibroblasts after fusion...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Glenn J. Markov, Thach Mai, Surag Nair, Anna Shcherbina, Yu Xin Wang, David M. Burns, Anshul Kundaje, Helen M. Blau Tags: Cell Biology Biological Sciences Source Type: research