Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency

Conclusions Our findings indicate that BDE-47 exposure during the early post-natal period induces a mild disturbance in glucose metabolism in susceptible mice with increased baseline insulin sensitivity. These results suggest an interaction between BDE-47 and genetic factors that regulate insulin signaling, which may result in long-term consequences.

http://link.springer.com/10.1186/s40608-014-0031-3

Source: BMC Obesity - February 7, 2015 Category: Eating Disorders and Weight Management Source Type: research