Nonlinear increase of pain in distance-based and area-based spatial summation

When nociceptive stimulation affects a larger body area, pain increases. This effect is called spatial summation of pain (SSp). The aim of this study was to describe SSp as a function of the size or distance of a stimulated area(s) and to test how this function is shaped by the intensity and SSp test paradigm. Thirty-one healthy volunteers participated in a within-subject experiment. Participants were exposed to area-based and distanced-based SSp. For area-based SSp, electrocutaneous noxious stimuli were applied by up to 5 electrodes (5 areas) forming a line-like pattern; for distance-based SSp, the same position and lengths of stimuli were used but only 2 electrodes were stimulated. Each paradigm was repeated using pain of low, moderate, and high intensity. It was found that the pattern of pain intensity followed a logarithmic (power) rather than a linear function. The dynamics of the pain increase were significantly different across pain intensities, with more summation occurring when pain was perceived as low. Results indicated that area-based SSp is more painful than distance-based SSp when low and moderate but not when high pain intensity is induced. Presented findings have important implications for all studies in which the spatial dimension of pain is measured. When the area or separation between nociceptive stimulation increases, pain does not increase linearly and the pattern of the pain increase is a result of the interaction between intensity and the number of noci...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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This study sheds new light on the functional capability of ECM LAMB1 in modulating pain plasticity and identifies a mechanism that conveys extracellular alterations to intracellular plasticity. Moreover, we identified cingulate LAMB1/integrin β1 signaling as a promising therapeutic target for the treatment of neuropathic pain and associated anxiodepression.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: Health News - - Category: Consumer Health News Source Type: news
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Source: - Category: Research Source Type: clinical trials
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Source: - Category: Research Source Type: clinical trials
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Oils and Fats Migraine Headaches Diet and Nutrition Omega-3 Fatty Acids Seafood Pain BMJ (Journal) ' Connor, Anahad Source Type: news
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Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
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Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - Category: Geriatrics Authors: Tags: An Aging World Featured Medical Articles Geriatric Medicine Long-Term Care Publications decubiti Jeff Levine MD Jeffrey M Levine MD pressure injuries pressure sore pressure sores pressure ulcer pressure ulcers wound care wound Source Type: blogs
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Source: - Daily MedNews - Category: General Medicine Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
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Source: Journal of Rheumatology - Category: Rheumatology Source Type: research
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