Nonlinear increase of pain in distance-based and area-based spatial summation

When nociceptive stimulation affects a larger body area, pain increases. This effect is called spatial summation of pain (SSp). The aim of this study was to describe SSp as a function of the size or distance of a stimulated area(s) and to test how this function is shaped by the intensity and SSp test paradigm. Thirty-one healthy volunteers participated in a within-subject experiment. Participants were exposed to area-based and distanced-based SSp. For area-based SSp, electrocutaneous noxious stimuli were applied by up to 5 electrodes (5 areas) forming a line-like pattern; for distance-based SSp, the same position and lengths of stimuli were used but only 2 electrodes were stimulated. Each paradigm was repeated using pain of low, moderate, and high intensity. It was found that the pattern of pain intensity followed a logarithmic (power) rather than a linear function. The dynamics of the pain increase were significantly different across pain intensities, with more summation occurring when pain was perceived as low. Results indicated that area-based SSp is more painful than distance-based SSp when low and moderate but not when high pain intensity is induced. Presented findings have important implications for all studies in which the spatial dimension of pain is measured. When the area or separation between nociceptive stimulation increases, pain does not increase linearly and the pattern of the pain increase is a result of the interaction between intensity and the number of noci...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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This study sheds new light on the functional capability of ECM LAMB1 in modulating pain plasticity and identifies a mechanism that conveys extracellular alterations to intracellular plasticity. Moreover, we identified cingulate LAMB1/integrin β1 signaling as a promising therapeutic target for the treatment of neuropathic pain and associated anxiodepression.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
A mobile app designed to provide low back pain sufferers with self-management tips to address their symptoms reduces disability caused by the condition, according to a study published by JAMA Internal Medicine.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Condition:   Myofascial Trigger Point Pain Interventions:   Other: Dry needling;   Other: Sham dry needling Sponsor:   Universitat Internacional de Catalunya Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Widespread Body Pain;   Fibromyalgia Interventions:   Other: Electromyographic measurement:;   Other: Ultrasonographic measurement: Sponsor:   Kutahya Health Sciences University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A diet high in omega-3s, the fats found in fish, and low in omega-6s, found in many vegetable oils, led to fewer headaches.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Oils and Fats Migraine Headaches Diet and Nutrition Omega-3 Fatty Acids Seafood Pain BMJ (Journal) ' Connor, Anahad Source Type: news
We present a 67-year-old female who presented with sudden onset abdominal pain and melena. An urgent contrast CT revealed type VI ISMAD. She underwent 3 staged operations as follows: (1) first, as laparotomy showed pale color in almost the extensive length of the small intestine, arterial bypassing of SMA was undertaken using SMA to the right common iliac artery bypass; (2) as the second-look operation on the next day, the terminal ileum was resected, and the remaining small intestine was able to be preserved. However, when the abdomen was tried to be closed, systemic blood pressure decreased to pre-shock condition, so the...
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
This is an “ear-saver” device which relieves pressure from the posterior ear and assists in preventing pressure injury to this sensitive area. My recent article in the June issue of Advances in Skin and Wound Care reviews the problem of pressure injury to the ear related to masks.  In the article I present a case report of a wound behind the ear of a long-term care resident who sustained a pressure injury to his ear from a mask.  Using this case as a springboard, the paper reviews anatomy of the ear, CDC regulations regarding PPE for nursing homes, staging and documentation of pressure injuries to the...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - Category: Geriatrics Authors: Tags: An Aging World Featured Medical Articles Geriatric Medicine Long-Term Care Publications decubiti Jeff Levine MD Jeffrey M Levine MD pressure injuries pressure sore pressure sores pressure ulcer pressure ulcers wound care wound Source Type: blogs
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The contact burn injury model is an experimental contact thermode-based physiological pain model primarily applied in research of drug efficacy in humans. The employment of the contact burn injury model across studies has been inconsistent regarding essent...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
J Rheumatol. 2021 Aug;48(8):1350. doi: 10.3899/jrheum.190162.C1.NO ABSTRACTPMID:34334355 | DOI:10.3899/jrheum.190162.C1
Source: Journal of Rheumatology - Category: Rheumatology Source Type: research
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