Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of VEXAS patients

Novel features of VEXAS include interstitial nephritis, cardiac involvement, stroke, and intestinal perforation related to treatment with tocilizumab. Early diagnosis could prevent unnecessary diagnostic procedures, and provide better prognostic information and more suitable treatment options.

Source: Journal of Allergy and Clinical Immunology - May 25, 2021 Category: Allergy & Immunology Authors: Caspar I. van der Made, Judith Potjewijd, Annemiek Hoogstins, Huub P.J. Willems, A.J. Kwakernaak, Ruud G.L. de Sevaux, Paul L.A. van Daele, Annet Simons, Marloes Heijstek, David B. Beck, Mihai G. Netea, Pieter van Paassen, A.E. Hak, Lars T. van der Veken, Source Type: research