The impact of Caspase-1 deletion on apoptosis and acute kidney injury in a murine transplant model

CONCLUSIONS: Our data suggest that other triggers of inflammation and programmed necrosis may need to be inhibited in addition to attenuating Caspase-1 to fully prevent AKI after kidney transplant. Importantly, requirements may be distinct for AKI induced by transplantation as opposed to other transient models such as the clamp model of AKI.PMID:33991613 | DOI:10.1016/j.cellsig.2021.110039
Source: Cellular Signalling - Category: Cytology Authors: Source Type: research