Pharmacokinetic interactions between ivacaftor and cytochrome P450 3A4 inhibitors in people with cystic fibrosis and healthy controls

Cystic Fibrosis (CF) is a severe, progressive, life-shortening inherited disease and is caused by mutations in the gene that encodes for a protein called the cystic fibrosis transmembrane conductance regulator (CFTR) [1,2]. This protein, an epithelial chloride channel, has important regulatory functions in various organs. Absence or dysfunction of this chloride channel causes symptoms in multi organ systems. Therefore, multiple drugs are needed to treat this complicated disease. Most therapies for CF treat the secondary consequence of the disease.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Letter to the Editor Source Type: research