MicroRNA-211 regulates the expression of TAB1 and inhibits the NF- κB signaling pathway in lipopolysaccharide-induced endometritis

This study aims to investigate the regulatory role of miR-211 in the innate immune response involved in endometritis, and to evaluate its potential therapeutic value. Here, we found that the expression of miR-211 in bovine endometrial epithelial cells (bEECs) stimulated by lipopolysaccharide (LPS) was significantly reduced. Importantly, overexpression of miR-211 can significantly reduce the production of pro-inflammatory cytokines (IL-1β , IL-6 and TNF-α). In addition, we proved that TAB1 is the target gene of miR-211. MiR-211 inhibits TAB1 protein expression by binding to the 3'-UTR of TAB1 mRNA. Subsequently, we verified that the overexpression of miR-211 inhibited the activation of NF-κB p65 by targeting the TAB1-mediated pathway. Therefore, miR-211 has anti-inflammatory effects and mediates the negative regulation of the NF-κB signaling pathway in LPS-induced endometritis by targeting TAB1.PMID:33984721 | DOI:10.1016/j.intimp.2021.107668

Source: International Immunopharmacology - May 13, 2021 Category: Allergy & Immunology Authors: Cheng Yang Chao Yang Jinxin Zhang Yingfang Guo Nuoer Chen Baoyi Yin Qingqing Zhou Tao Zhang Shuai Guo Ganzhen Deng Source Type: research