Ginkgolide B derivative synthesis and their effects on the viability of SKOV3 cells

AbstractThe natural product Ginkgolide B was used as a raw material and modified by esterification on C10-OH or C1-OH to obtain 11 derivatives (1–11), which were structurally characterized with nuclear magnetic resonance spectroscopy. An MTT assay-based in vitro tumor proliferation inhibitory activity test showed that compounds2,3,6,7,10, and11 exhibited strong inhibitory activity against the human ovarian cancer cells SKOV3, with IC50 values of 16.05  µmol/L, 15.65 µmol/L, 32.00 µmol/L, 63.30 µmol/L, 23.20 µmol/L, and 31.10 µmol/L, respectively. Annexin V/PI double staining assay showed that compound2 induced apoptosis in SKOV3 cells to a slightly greater extent than GB and compounds5 and9, with an apoptosis rate of 31.68%.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research