Targeting Neuromyelitis Optica Pathogenesis: Results from Randomized Controlled Trials of Biologics

AbstractAdvances in neuromyelitis optica spectrum disorder pathogenesis have allowed the development of targeted drugs. These treatments act on core elements of the disease, including the pro-inflammatory IL-6 pathway (tocilizumab and satralizumab), B cells (rituximab and inebilizumab), and complement (eculizumab). According to recent phase II –III trials, biologics significantly reduced the risk of relapses in aquaporin-4-seropositive patients, whereas results were less striking in the small cohorts of aquaporin-4-seronegative patients. Most adverse events were mild to moderate, with systemic symptoms (headache, arthralgia) or infectio ns (upper respiratory and urinary tracts) being most commonly reported.

http://link.springer.com/10.1007/s13311-021-01055-0

Source: Neurotherapeutics - April 28, 2021 Category: Neurology Source Type: research