O18  Integrated molecular analysis of systemic sclerosis skin and blood shows significant differences between major autoantibody subgroups

Conclusion We have found significant differences in skin gene expression and longitudinal change in serum markers by autoantibody specificity in dcSSc. Our findings have implications for SSc pathogenesis and support stratification by ANA subgroup in clinical studies.Disclosure K.E. Clark: None.C. Campochiaro: None.E. Csomor: Corporate appointments; employee of GSK.A. Taylor: Corporate appointments; employee of GSK.K. Nevin: Corporate appointments; employee of GSK.N. Galwey: Corporate appointments; employee of GSK.M.A. Morse: Corporate appointments; employee of GSK.V.H. Ong: None.E. Derrett-Smith: None.N. Wisniacki: Corporate appointments; employee of GSK.S. Flint: Corporate appointments; employee of GSK.C.P. Denton: Consultancies; Actelion, GlaxoSmithKline, Bayer, Sanofi, lnventiva, Boehringer Ingelheim, Roche, Bristol Myers Squibb, CSL Behring, UCB, Leadiant Biosciences, Corbus, Servier, Arxx Therapeutics.
Source: Rheumatology - Category: Rheumatology Source Type: research