Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme enzyme that catalyzes the oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune escape via catalyzing the initial step of the kynu...

Source: Journal of Hematology and Oncology - April 21, 2021 Category: Hematology Authors: Kai Tang, Ya-Hong Wu, Yihui Song and Bin Yu Tags: Review Source Type: research