Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities

This article reviews recent advances in our knowledge of microglia with emphases on molecular mediators of phenotype shifts and functional diversity. We describe microglia-targeted therapeutic opportunities, including pharmacologic modulation of phenotype and repopulation of the brain with fresh microglia. With the advent of powerful new tools, research on microglia has recently accelerated in pace and may translate into potential therapeutics against brain injury and neurological disease.

Source: Translational Stroke Research - April 20, 2021 Category: Neurology Source Type: research