Cancers, Vol. 13, Pages 1941: Biomarker-Guided Anti-Egfr Rechallenge Therapy in Metastatic Colorectal Cancer

Cancers, Vol. 13, Pages 1941: Biomarker-Guided Anti-Egfr Rechallenge Therapy in Metastatic Colorectal Cancer Cancers doi: 10.3390/cancers13081941 Authors: Davide Ciardiello Giulia Martini Vincenzo Famiglietti Stefania Napolitano Vincenzo De Falco Teresa Troiani Tiziana Pia Latiano Javier Ros Elena Elez Fernandez Pietro Paolo Vitiello Evaristo Maiello Fortunato Ciardiello Erika Martinelli The prognosis of patients with metastatic colorectal cancer (mCRC) who progressed to the first and the second lines of treatment is poor. Thus, new therapeutic strategies are needed. During the last years, emerging evidence suggests that retreatment with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MAbs) in the third line of mCRC patients, that have previously obtained clinical benefit by first-line therapy with anti-EGFR MAbs plus chemotherapy, could lead to prolonged survival. The rationale beyond this “rechallenge” strategy is that, after disease progression to first line EGFR-based therapy, a treatment break from anti-EGFR drugs results in RAS mutant cancer cell decay, restoring the sensitivity of cancer cells to cetuximab and panitumumab. In fact, rechallenge treatment with anti-EGFR drugs has shown promising clinical activity, particularly in patients with plasma RAS and BRAF wild type circulating tumor DNA, as defined by liquid biopsy analysis at baseline treatment. The aim of this review is to analyze the current knowledge on ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research