Cancers, Vol. 13, Pages 1916: Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors

Cancers, Vol. 13, Pages 1916: Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors Cancers doi: 10.3390/cancers13081916 Authors: Ziad Omran Mahmood H. Dalhat Omeima Abdullah Mohammed Kaleem Salman Hosawi Fahd A Al-Abbasi Wei Wu Hani Choudhry Mahmoud Alhosin The tumor suppressor p73 is a member of the p53 family and is expressed as different isoforms with opposing properties. The TAp73 isoforms act as tumor suppressors and have pro-apoptotic effects, whereas the ΔNp73 isoforms lack the N-terminus transactivation domain and behave as oncogenes. The TAp73 protein has a high degree of similarity with both p53 function and structure, and it induces the regulation of various genes involved in the cell cycle and apoptosis. Unlike those of the p53 gene, the mutations in the p73 gene are very rare in tumors. Cancer cells have developed several mechanisms to inhibit the activity and/or expression of p73, from the hypermethylation of its promoter to the modulation of the ratio between its pro- and anti-apoptotic isoforms. The p73 protein is also decorated by a panel of post-translational modifications, including phosphorylation, acetylation, ubiquitin proteasomal pathway modifications, and small ubiquitin-related modifier (SUMO)ylation, that regulate its transcriptional activity, subcellular localization, and stability. These modifications orchestrate the multiple anti-proliferative and pro-apoptotic functio...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research