Setting molecular traps in yeast for identification of anticancer drug targets [Genetics]

Almost 25 y have passed since Lee Hartwell et al. (1) proposed that systematic efforts to map genetic interactions in model systems promised to accelerate identification of new anticancer drug targets that exploit the unique molecular context of tumor cells. Synthetic lethal interactions, in which mutation of a gene causes...

Source: Proceedings of the National Academy of Sciences - April 14, 2021 Category: Science Authors: Grant W. Brown, Brenda Andrews Tags: Genetics, Commentaries Commentary Source Type: research