A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis [Cell Biology]

The autophagy protein ATG2, proposed to transfer bulk lipid from the endoplasmic reticulum (ER) during autophagosome biogenesis, interacts with ER residents TMEM41B and VMP1 and with ATG9, in Golgi-derived vesicles that initiate autophagosome formation. In vitro assays reveal TMEM41B, VMP1, and ATG9 as scramblases. We propose a model wherein membrane...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Cell Biology, Brief Reports Biological Sciences Source Type: research